Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 8/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574455 | 0.89 | KMT2A (0.50) | HTR4HTR2AHTR2CHTR2B | |
| SCHEMBL7357981 | 0.87 | HTR4 (0.67) | HTR4ALDH1A1ACHEGAA | |
| SCHEMBL8569585 | 0.84 | HTR4 (0.50) | HTR4ALDH1A1ACHEGAA | |
| SCHEMBL7355259 | 0.83 | AGER (0.53) | HTR4ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL11836438 | 0.81 | STING1 (0.57) | HTR4ALDH1A1ACHE | |
| SCHEMBL6702779 | 0.81 | MEN1 (0.52) | HTR4HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL8571105 | 0.81 | HTR2A (0.55) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL8572360 | 0.81 | HTR2A (0.54) | HTR4HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL17844481 | 0.80 | STING1 (0.46) | HTR4ALDH1A1ACHESMN1; SMN2LMNA | |
| SCHEMBL8572525 | 0.79 | ALDH1A1 (0.56) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |