Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 9/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574455 | 0.88 | KMT2A (0.50) | HTR4MEN1KMT2ACYP3A4HDAC8 | |
| SCHEMBL7357981 | 0.86 | HTR4 (0.67) | HTR4GAAACHEMEN1ALDH1A1 | |
| SCHEMBL8575158 | 0.84 | HTR4 (0.51) | HTR4GAAACHEALDH1A1 | |
| SCHEMBL8572525 | 0.78 | ALDH1A1 (0.56) | MEN1ALDH1A1KMT2AHDAC8HDAC1 | |
| SCHEMBL8570776 | 0.78 | ALDH1A1 (0.42) | HTR4MEN1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL8571284 | 0.77 | RAB9A (0.58) | MEN1ALDH1A1KMT2AHDAC1 | |
| SCHEMBL8571105 | 0.77 | HTR2A (0.55) | MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL8572360 | 0.77 | HTR2A (0.54) | HTR4MEN1ALDH1A1KMT2AHDAC8 | |
| SCHEMBL8569807 | 0.77 | KMT2A (0.53) | MEN1ALDH1A1TSHRKMT2AHDAC8 | |
| SCHEMBL29156702 | 0.76 | KDM4E (0.50) | HTR4GAAACHEALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |