Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574636 | 0.82 | SIRT2 (0.42) | SIRT1SIRT2MEN1KMT2ACASP1 | |
| SCHEMBL3258128 | 0.81 | SIRT1 (0.63) | SIRT1SIRT2CASP1 | |
| SCHEMBL8595169 | 0.77 | SIRT1 (0.50) | SIRT1SIRT2CASP1 | |
| Sulfuric Acid SCHEMBL8592514 | 0.76 | SIRT1 (0.57) | SIRT1SIRT2CASP1 | |
| SCHEMBL11848642 | 0.75 | KDM4E (0.50) | SIRT1SIRT2MEN1ALOX15TSHR | |
| SCHEMBL901479 | 0.72 | TSPO (0.55) | SIRT1SIRT2ALOX15 | |
| SCHEMBL11835576 | 0.70 | GABRA1 (0.44) | SIRT1SIRT2TSHRCASP1 | |
| SCHEMBL11844570 | 0.70 | SIRT2 (0.43) | SIRT1SIRT2MEN1ALOX15KMT2A | |
| SCHEMBL28912217 | 0.68 | NR2E1 (0.50) | SIRT1SIRT2 | |
| SCHEMBL14473893 | 0.68 | BRD3 (0.58) | SIRT1SIRT2TSHRCASP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018464-A1 | SUBSTITUTED TRICYCLICS | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |