SCHEMBL8575860

SCHEMBL8575860

NC1C[N]CCC(Nc2ccc(F)c(Cl)c2)C1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 9/20 0.43
CDK2 P24941 8/20 0.43
ROCK2 O75116 1/20 0.43
MAPK9 P45984 1/20 0.43
GSK3B P49841 1/20 0.43
MAP2K1 Q02750 1/20 0.43
MAPKAPK5 Q8IW41 1/20 0.43
KCNH2 Q12809 1/20 0.42
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CHEK2 O96017 1/20 0.41
CDK1 P06493 1/20 0.41
CSNK1D P48730 1/20 0.41
CDK5 Q00535 1/20 0.41
MAPKAPK3 Q16644 1/20 0.41
TRPA1 O75762 1/20 0.39
HPGD P15428 1/20 0.39
NR1I2 O75469 1/20 0.38
AHR P35869 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8573402 0.82 KMT2A (0.43) MAPKAPK2CDK2ROCK2MAPK9GSK3B
SCHEMBL8573924 0.76 CDK2 (0.42) MAPKAPK2CDK2ROCK2MAPK9GSK3B
SCHEMBL8572544 0.76 KMT2A (0.46) KMT2AMEN1ALDH1A1TRPA1HPGD
SCHEMBL31453688 0.75 KMT2A (0.59) MAPKAPK2CDK2ROCK2MAPK9GSK3B
SCHEMBL9008342 0.75 KMT2A (0.59) MAPKAPK2CDK2ROCK2MAPK9GSK3B
SCHEMBL8574021 0.75 TRPA1 (0.40) MAPKAPK2CDK2ROCK2MAPK9GSK3B
SCHEMBL8664359 0.73 ALDH1A1 (0.40) KCNH2KMT2AMEN1ALDH1A1TRPA1
SCHEMBL8574961 0.72 MAPT (0.41) KCNH2KMT2AMEN1ALDH1A1TRPA1
SCHEMBL8575750 0.71 MAPT (0.41) KCNH2KMT2AMEN1ALDH1A1TRPA1
SCHEMBL8574078 0.71 MAPKAPK2 (0.42) MAPKAPK2CDK2KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5821240-A ENZYME INHIBITORS, SIGNAL INHIBITORS FOR ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS AND HORMONE INHIBITORS DR. KARL THOMAE GMBH (DE) 1998-10-13 US disclosed