Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.41 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | TYR | P14679 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.36 |
| ▸ | GLRB | P48167 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7877558 | 0.91 | ALDH1A1 (0.39) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL26179223 | 0.91 | ALDH1A1 (0.39) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL13945794 | 0.90 | ALDH1A1 (0.43) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL25797098 | 0.89 | KIF11 (0.36) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL12732373 | 0.84 | CYP1A2 (0.37) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL17083896 | 0.82 | SMN1; SMN2 (0.37) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL16512750 | 0.82 | ALOX15 (0.64) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL17030743 | 0.82 | ALDH1A1 (0.56) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL16658361 | 0.82 | ALDH1A1 (0.36) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL26762111 | 0.82 | KDM1A (0.33) | ALDH1A1ALOX15SMN1; SMN2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051762-A1 | POLYCATIONIC COMPOUNDS AND USES THEREOF | POLYMEDIX, INC. | 2014-02-20 | — | — | US | disclosed |
| EP-2537875-A1 | NOVEL POLYAZOMETHINE | Soken Chemical & Engineering Co., Ltd. (JP) | 2012-12-26 | — | — | EP | disclosed |
| US-8232428-B2 | Polycationic compounds and uses thereof | PolyMedix,Inc. (US) | 2012-07-31 | — | — | US | disclosed |
| US-8129566-B2 | Polycationic compounds and uses thereof | POLYMEDIX, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129566-B2 | Polycationic compounds and uses thereof | POLYMEDIX, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110124664-A1 | Polycationic Compounds And Uses Thereof | POLYMEDIX, INC. (US) | 2011-05-26 | — | — | US | disclosed |
| US-20110124664-A1 | Polycationic Compounds And Uses Thereof | POLYMEDIX, INC. (US) | 2011-05-26 | — | — | US | disclosed |
| US-20100298344-A1 | Polycationic Compounds And Uses Thereof | POLYMEDIX, INC. | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298344-A1 | Polycationic Compounds And Uses Thereof | VEGFA, VHL, PGF | ALDH1A1 3071/4885ALOX15 1107/4885SMN1; SMN2 4701/4885 |
| US-20110124664-A1 | Polycationic Compounds And Uses Thereof | VEGFA, VHL, PGF | ALDH1A1 3071/4885ALOX15 1107/4885SMN1; SMN2 4701/4885 |
| US-20140051762-A1 | POLYCATIONIC COMPOUNDS AND USES THEREOF | VEGFA, VHL, PGF | ALDH1A1 3071/4885ALOX15 1107/4885SMN1; SMN2 4701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.