Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 3/20 | 0.36 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | NOS2 | P35228 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 2/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiourea SCHEMBL8576993 | 0.88 | BLM (0.43) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Sulfuric Acid SCHEMBL27815548 | 0.84 | BLM (0.52) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Pimagedine SCHEMBL30862137 | 0.83 | CYP2C19 (0.40) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Hydroxyamine SCHEMBL6141650 | 0.82 | — | — | |
| Hydroxyamine SCHEMBL7541307 | 0.82 | BLM (0.44) | BLMCYP2C19CYP2D6KDM4ENPSR1 | |
| Methylamine SCHEMBL6763378 | 0.82 | — | — | |
| SCHEMBL2058760 | 0.82 | CA5A (0.46) | BLMCYP2C19KDM4ELMNASLC6A6 | |
| SCHEMBL1904 | 0.82 | — | — | |
| SCHEMBL126970 | 0.82 | — | — | |
| Acetamide SCHEMBL28709825 | 0.80 | BLM (0.53) | BLMCYP2C19CYP2D6KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0744619-B1 | Ascorbate resistant detection of hydrogen peroxide | BAYER AG (US) | 1998-07-29 | — | — | EP | disclosed |
| EP-0744619-A1 | Ascorbate resistant detection of hydrogen peroxide | Bayer Corporation (US) | 1996-11-27 | — | — | EP | disclosed |