SCHEMBL8577610

SCHEMBL8577610

O=C(CBr)c1cncnc1C(F)(F)Cl

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 3/20 0.34
GSK3B P49841 2/20 0.34
ITGB1 P05556 1/20 0.32
ITGA4 P13612 1/20 0.32
SYK P43405 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8566575 0.83 ALDH1A1 (0.38) ITGB1ITGA4
SCHEMBL8558082 0.78 ALDH1A1 (0.34) ITGB1ITGA4SYK
SCHEMBL30843825 0.76 GSK3B (0.37) PTPN1GSK3B
SCHEMBL8566193 0.75 SYK (0.34) ITGB1ITGA4SYK
SCHEMBL8560086 0.73 CYP11B2 (0.37) ITGB1ITGA4SYK
SCHEMBL8565951 0.71 ADORA1 (0.44)
SCHEMBL8176736 0.70
SCHEMBL1671209 0.67 ASPH (0.43) ITGB1ITGA4SYK
SCHEMBL23204596 0.67 NTRK1 (0.42) PTPN1
SCHEMBL13784460 0.66 CYP11B1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5773388-A Pyrimidine derivatives, herbicides and plant growth regulators NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-06-30 US disclosed
EP-0713872-A1 NOVEL PYRIMIDINE DERIVATIVE, HERBICIDE AND PLANT GROWTH REGULATOR NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1996-05-29 EP disclosed