SCHEMBL8577983

SCHEMBL8577983

C=C(C)C(=O)NC(CS(=O)(=O)O)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 1/20 0.41
ALDH1A1 P00352 5/20 0.41
KDM4E B2RXH2 2/20 0.41
KCNA5 P22460 3/20 0.39
LMNA P02545 3/20 0.38
HPGD P15428 2/20 0.38
POLB P06746 1/20 0.38
TSHR P16473 1/20 0.38
HSD17B10 Q99714 1/20 0.38
RIPK1 Q13546 1/20 0.38
SRC P12931 1/20 0.37
ATM Q13315 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MTNR1A P48039 1/20 0.36
MTNR1B P49286 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9068085 0.80 SMN1; SMN2 (0.47) ALDH1A1KDM4EATML3MBTL1
SCHEMBL28201839 0.79 ALDH1A1 (0.59) ALDH1A1MTNR1AMTNR1B
SCHEMBL27725242 0.79 LMNA (0.50) ALDH1A1KDM4EKCNA5LMNAHPGD
SCHEMBL8755345 0.78 ALDH1A1 (0.38) ALDH1A1KDM4EKCNA5LMNAHPGD
SCHEMBL5858432 0.78 TGM2 (0.45) ALDH1A1KDM4EKCNA5LMNAHPGD
SCHEMBL10634749 0.77 TGM2 (0.44) ALDH1A1KDM4EKCNA5LMNAPOLB
SCHEMBL11063512 0.77 KMT2A (0.41) TGFBR1ALDH1A1KDM4ELMNAHPGD
Diphenylamine SCHEMBL11692048 0.76 ALDH1A1 (0.44) TGFBR1ALDH1A1KDM4ELMNAHPGD
SCHEMBL10000908 0.76 ALDH1A1 (0.39) TGFBR1ALDH1A1KDM4EKCNA5LMNA
SCHEMBL18329135 0.75 MEN1 (0.47) ALDH1A1KDM4EKCNA5LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160369017-A1 CURABLE COMPOSITION, POLYMER FUNCTIONAL CURED PRODUCT, WATER-SOLUBLE ACRYLAMIDE COMPOUND, AND METHOD FOR MANUFACTURING SAME FUJIFILM CORPORATION (JP) 2016-12-22 US disclosed
US-20160369017-A1 CURABLE COMPOSITION, POLYMER FUNCTIONAL CURED PRODUCT, WATER-SOLUBLE ACRYLAMIDE COMPOUND, AND METHOD FOR MANUFACTURING SAME FUJIFILM CORPORATION (JP) 2016-12-22 US disclosed
US-5787686-A CONTAINING WATER INSOLUBLE AGRICULTURE PESTICIDE THE DOW CHEMICAL COMPANY (US) 1998-08-04 US disclosed
US-5753766-A Amphipathic graft copolymers and copolymer compositions and methods of making THE DOW CHEMICAL COMPANY (US) 1998-05-19 US disclosed
US-5753248-A Amphipathic graft copolymer pesticide formulation compositions and methods of their use THE DOW CHEMICAL COMPANY (US) 1998-05-19 US disclosed
EP-0766705-B1 PREPARATION OF AMPHIPATHIC GRAFT COPOLYMERS, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE DOW CHEMICAL CO (US) 1998-05-13 EP disclosed
US-5693716-A Amphipathic graft copolymers and copolymer compositions and methods of making THE DOW CHEMICAL COMPANY (US) 1997-12-02 US disclosed
CN-1159199-A Novel amphipathic graft copolymers, their prepn., compositions thereof and methods of their use DOW CHEMICAL CO (US) 1997-09-10 CN disclosed
EP-0766705-A1 PREPARATION OF AMPHIPATHIC GRAFT COPOLYMERS, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE THE DOW CHEMICAL COMPANY (US) 1997-04-09 EP disclosed
WO-1996000251-A1 NOVEL AMPHIPATHIC GRAFT COPOLYMERS, THEIR PREPARATION, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE THE DOW CHEMICAL COMPANY (US) 1996-01-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160369017-A1 CURABLE COMPOSITION, POLYMER FUNCTIONAL CURED PRODUCT, WATER-SOLUBLE ACRYLAMIDE COMPOUND, AND METHOD FOR MANUFACTURING SAME MRPL21, WDR1, CCNT1 TGFBR1 154/4885ALDH1A1 66/4885KDM4E 2714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.