SCHEMBL8579591

SCHEMBL8579591

CC(C)Oc1cc(N=C=S)c(F)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPOX P50336 3/20 0.38
CSNK2A1 P68400 2/20 0.36
GAA P10253 1/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
LMNA P02545 1/20 0.34
NAAA Q02083 1/20 0.33
RORC P51449 1/20 0.33
KDM4E B2RXH2 2/20 0.32
NR1I2 O75469 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MAP2 P11137 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10545794 0.87
SCHEMBL8598170 0.86 DHODH (0.35) PPOX
SCHEMBL8602842 0.86
SCHEMBL7021771 0.85 PPOX (0.40) PPOXCSNK2A1GAAMEN1KMT2A
SCHEMBL8601346 0.85
SCHEMBL8599137 0.84 KDM4E (0.42) PPOXGAAKMT2AKDM4ETDP1
SCHEMBL8599592 0.83 PPOX (0.38) PPOXLMNAKDM4EALDH1A1HPGD
SCHEMBL10440375 0.83 NAAA (0.33) NAAA
SCHEMBL7535311 0.83 NPC1 (0.38) PPOXGAAMEN1KMT2ALMNA
SCHEMBL10824307 0.82 NAAA (0.33) NAAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0626370-B1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL CO (JP) 1998-02-11 EP disclosed
US-5712225-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1998-01-27 US disclosed
EP-0716655-A1 OXA- AND THIA (DI)AZABICYCLIC COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-06-19 EP disclosed
US-5416065-A Herbicidal thiadiazabicyclooctanes CIBA-GEIGY CORPORATION (US) 1995-05-16 US disclosed
WO-1995006643-A1 OXA- AND THIA (DI)AZABICYCLIC COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-03-09 WO disclosed
EP-0626370-A1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1994-11-30 EP disclosed
EP-0600833-A1 Herbicidal thiediazabicyclo-octanes CIBA-GEIGY AG (CH) 1994-06-08 EP disclosed
US-5039331-A Condensed heterocyclic derivatives and herbicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1991-08-13 US disclosed
EP-0304920-A2 Condensed heterocyclic derivatives, process for their production and herbicides NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1989-03-01 EP disclosed
US-4622063-A 4-(2-fluoro-4-halo-5-substituted phenyl)urazols, and herbicidal use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1986-11-11 US disclosed
US-4593094-A INTERMEDIATES FOR HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1986-06-03 US disclosed
EP-0075267-B1 4-(2-FLUORO-4-HALO-5-SUBSTITUTED PHENYL)URAZOLS, AND THEIR PRODUCTION AND USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1986-01-15 EP disclosed
US-4452981-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-06-05 US disclosed
EP-0075267-A1 4-(2-Fluoro-4-halo-5-substituted phenyl)urazols, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-03-30 EP disclosed