Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8581523 | 0.72 | ALDH1A1 (0.42) | KDM4EALDH1A1GAAHSD17B10GLA | |
| SCHEMBL9752488 | 0.71 | MAPT (0.37) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL17620565 | 0.70 | KDM4E (0.53) | KDM4EALDH1A1GAAHSD17B10GLA | |
| SCHEMBL8603348 | 0.70 | KMT2A (0.33) | KDM4EALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL8576911 | 0.68 | HSD17B10 (0.53) | KDM4EALDH1A1GAAHSD17B10GLA | |
| SCHEMBL21886150 | 0.66 | KDM4E (0.43) | KDM4EALDH1A1GAAHSD17B10GLA | |
| SCHEMBL9600939 | 0.65 | HSD11B1 (0.39) | KDM4EALDH1A1MAPT | |
| SCHEMBL19233623 | 0.63 | MAPT (0.33) | KDM4EALDH1A1GAAHSD17B10GLA | |
| SCHEMBL370015 | 0.63 | KDM4E (0.37) | KDM4EALDH1A1GAAHSD17B10GLA | |
| SCHEMBL9752552 | 0.62 | ALDH1A1 (0.37) | KDM4EALDH1A1GAAHSD17B10GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756501-A | USEFUL FOR TREATING ALZHIMER'S DISEASE, DOWN'S SYNDROM AND PARKINSON'S DISEASE INVOLVING HYPOFUNCTION OF ACETYLCHOLINE IN MAMMAL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |