Fluoride

Fluoride

SCHEMBL8583071

C=C(C)C(=O)NCCCC(C)N(C)C.F

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 11/20 0.46
CHRNA4 P43681 11/20 0.46
CHRNB4 P30926 9/20 0.46
CHRNA3 P32297 7/20 0.40
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 1/20 0.32
TGFBR1 P36897 1/20 0.32
MAPK1 P28482 1/20 0.31
HIF1A Q16665 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11283812 0.92 CHRNB2 (0.45) CHRNB2CHRNA4CHRNB4CHRNA3KDM4E
SCHEMBL1903516 0.88 CHRNB2 (0.59) CHRNB2CHRNA4CHRNB4CHRNA3TGFBR1
SCHEMBL9321568 0.84 CHRNB2 (0.37) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL2802696 0.82 CCR2 (0.34) CHRNB2CHRNA4CHRNB4KDM4EALDH1A1
SCHEMBL25557372 0.80 ANPEP (0.41) KDM4EALDH1A1TGFBR1MAPK1HIF1A
SCHEMBL16553786 0.79 TGFBR1 (0.38) CHRNB2CHRNA4CHRNB4CHRNA3KDM4E
SCHEMBL19970620 0.79 CHRNB2 (0.34) CHRNB2CHRNA4CHRNB4KDM4ETGFBR1
Fluoride SCHEMBL8582350 0.78 DPP7 (0.30) KDM4E
SCHEMBL11278512 0.78 DPP7 (0.35) CHRNB2CHRNA4CHRNB4KDM4EALDH1A1
SCHEMBL1147853 0.77 CHRNB2 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5705581-A QUATERNARIUM ALKYL ACRYLAMIDES WITH FLUORIDE ION FOR DENTAL FILLINGS INDIANA UNIVERSITY FOUNDATION (US) 1998-01-06 US claimed
US-5705581-A QUATERNARIUM ALKYL ACRYLAMIDES WITH FLUORIDE ION FOR DENTAL FILLINGS INDIANA UNIVERSITY FOUNDATION (US) 1998-01-06 US disclosed
US-5639840-A METHACRYLIC ACID-BASED MONOMERS INDIANA UNIVERSITY FOUNDATION (US) 1997-06-17 US disclosed