SCHEMBL8583128

SCHEMBL8583128

FC(F)C(F)(F)Oc1ccc(C2CNCC[N]2)cc1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 1/20 0.35
TRPV1 Q8NER1 3/20 0.34
MMP13 P45452 1/20 0.33
MMP14 P50281 1/20 0.33
KCNH2 Q12809 1/20 0.33
JAK2 O60674 1/20 0.32
JAK1 P23458 1/20 0.32
JAK3 P52333 1/20 0.32
SCN10A Q9Y5Y9 1/20 0.32
HTR2C P28335 1/20 0.30
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8582071 0.82 HTT (0.38) MMP13MMP14ALDH1A1TSHR
SCHEMBL8583104 0.78 SCN5A (0.36)
SCHEMBL9331689 0.76 MAOA (0.50) NISCHHTR2CALDH1A1
SCHEMBL9363501 0.76 HTR2C (0.49) NISCHHTR2C
SCHEMBL8581573 0.76 MMP13 (0.35) MMP13MMP14
SCHEMBL1616732 0.74 KDM1A (0.38)
SCHEMBL6073380 0.74 KDM1A (0.46) NISCHKCNH2ALDH1A1TSHR
SCHEMBL10518245 0.72 MAOA (0.54) TSHR
SCHEMBL9375602 0.71 CYP19A1 (0.33)
SCHEMBL10520604 0.71 TAAR1 (0.39) KCNH2HTR2CTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5814324-A OIL IN WATER EMULSION COMPRISING ANTIFUNGAL TRIAZOLE COMPOUND DISPERSED IN WATER WITH FATTY ACID TRIGLYCERIDE, LECITHIN EMULSIFIER TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-29 US disclosed
US-5792780-A FUNGICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-08-11 US disclosed
US-5677464-A Production of optically active triazole compounds and their intermediates TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-14 US disclosed