Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587032 | 0.85 | GRIA4 (0.48) | GRIA4ALDH1A1NPC1RAB9A | |
| SCHEMBL8583394 | 0.85 | ALDH1A1 (0.38) | CA12CA9CA1CA2SMN1; SMN2 | |
| SCHEMBL7570581 | 0.84 | CA12 (0.43) | CA12CA9CA1CA2SMN1; SMN2 | |
| SCHEMBL8583981 | 0.84 | LTB4R2 (0.38) | CA12CA9GRIA4KDM4EALDH1A1 | |
| SCHEMBL8584767 | 0.83 | XDH (0.36) | CA12CA9SMN1; SMN2GRIA4KDM4E | |
| SCHEMBL8585276 | 0.81 | ALDH1A1 (0.40) | CA12CA9CA1CA2GRIA4 | |
| SCHEMBL9229027 | 0.81 | CA12 (0.47) | CA12CA9CA1CA2ALDH1A1 | |
| SCHEMBL8584956 | 0.78 | EPHX2 (0.38) | CA12CA9CA1CA2KCNH2 | |
| SCHEMBL8587469 | 0.77 | KIF11 (0.51) | CA1CA2 | |
| SCHEMBL8585567 | 0.77 | L3MBTL1 (0.43) | CA12CA9CA1CA2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998033496-A1 | SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1998-08-06 | — | — | WO | disclosed |