Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.43 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10008740 | 0.81 | DRD2 (0.64) | SLC6A4SLC6A3SLC6A2ALDH1A1TSHR | |
| SCHEMBL1267331 | 0.79 | ALDH1A1 (0.55) | SLC6A4SLC6A3SLC6A2ALDH1A1TSHR | |
| SCHEMBL6747981 | 0.77 | SIGMAR1 (0.56) | ALDH1A1TSHRDRD2DRD3HTR1A | |
| SCHEMBL31028212 | 0.74 | OPRM1 (0.46) | SLC6A4SLC6A3SLC6A2ALDH1A1TSHR | |
| SCHEMBL5194656 | 0.74 | SLC6A4 (0.74) | SLC6A4SLC6A3SLC6A2ALDH1A1DRD2 | |
| SCHEMBL5193526 | 0.72 | ALDH1A1 (0.52) | SLC6A4SLC6A3SLC6A2ALDH1A1DRD2 | |
| SCHEMBL29965651 | 0.72 | SIGMAR1 (0.72) | ALDH1A1TSHRDRD2DRD3SIGMAR1 | |
| SCHEMBL7542807 | 0.72 | SIGMAR1 (0.72) | ALDH1A1TSHRDRD2DRD3SIGMAR1 | |
| SCHEMBL5566258 | 0.71 | SLC6A4 (0.64) | SLC6A4SLC6A3SLC6A2ALDH1A1OPRM1 | |
| SCHEMBL5349498 | 0.70 | SIGMAR1 (0.70) | ALDH1A1TSHRSIGMAR1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819126-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031508-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-10 | — | — | WO | disclosed |