SCHEMBL8587107

SCHEMBL8587107

O=P(O)(O)C(=S)P(=O)(O)Oc1ccc(Sc2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.42
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
MMP2 P08253 1/20 0.35
MMP9 P14780 1/20 0.35
MMP12 P39900 1/20 0.35
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA4 P22748 2/20 0.34
CA5A P35218 2/20 0.34
CA7 P43166 2/20 0.34
CA9 Q16790 2/20 0.34
CA5B Q9Y2D0 2/20 0.34
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CTSK P43235 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
BCL2 P10415 1/20 0.33
MCL1 Q07820 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8091468 0.81 PLK1 (0.36) SRCALDH1A1HPGDCA1CA2
SCHEMBL8589340 0.77 BLM (0.37) ALDH1A1SMN1; SMN2MAOA
SCHEMBL8589711 0.76 CA2 (0.40) ALDH1A1CA12CA1CA2CA7
SCHEMBL8083418 0.75 ACP3 (0.42) HPGDMMP2CA12CA1CA2
SCHEMBL3799753 0.75 MEN1 (0.50) SRCALDH1A1HPGDMMP2MMP9
SCHEMBL9410426 0.73 SRC (0.43) SRCALDH1A1HPGDMMP2MMP9
SCHEMBL8587455 0.73 SMN1; SMN2 (0.39) SRCALDH1A1HPGDSMN1; SMN2MEN1
SCHEMBL16997494 0.72 CYP3A4 (0.48) SRCALDH1A1HPGDCA12CA1
SCHEMBL8589186 0.72 SLC6A4 (0.39) ALDH1A1SMN1; SMN2LMNA
SCHEMBL9410421 0.71 L3MBTL1 (0.41) SRCALDH1A1HPGDMMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0594857-B1 METHANEDIPHOSPHONIC ACID DERIVATIVE, PRODUCTION THEREOF AND MEDICINAL USE THEREOF TORAY INDUSTRIES (JP) 1998-04-29 EP disclosed
US-5683992-A TREATMENT OF RHEUMATISM, BONE DISORDERS, ANTIINFLAMMATORY, SUPPRESSION OF INTERLEUKIN-1, ANTIOXIDANT, TREATMENT OF AUTOIMMUNE DISEASES TORAY INDUSTRIES, INC. (JP) 1997-11-04 US disclosed
US-5527940-A SUPPRESSES INTERLEUKIN-1 AND BONE DESTRUCTION DURING OSTEOPOROSIS; ANTIINFLAMMATORY AGENTS TORAY INDUSTRIES, INC. (JP) 1996-06-18 US disclosed
EP-0594857-A1 METHANEDIPHOSPHONIC ACID DERIVATIVE, PRODUCTION THEREOF AND MEDICINAL USE THEREOF TORAY INDUSTRIES, INC. (JP) 1994-05-04 EP disclosed