SCHEMBL8091468

SCHEMBL8091468

CSc1ccc(OP(=O)(O)C(=S)P(=O)(O)O)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 1/20 0.36
CYP1A1 P04798 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP1B1 Q16678 1/20 0.35
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
MAPT P10636 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
BLM P54132 1/20 0.33
IDO1 P14902 1/20 0.33
CYP2C19 P33261 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
ALDH1A1 P00352 3/20 0.32
CYP3A4 P08684 1/20 0.32
TSHR P16473 1/20 0.32
SRC P12931 1/20 0.32
MAOB P27338 1/20 0.32
AOC3 Q16853 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8589340 0.83 BLM (0.37) SMN1; SMN2BLMCYP2C19ALDH1A1
SCHEMBL8587462 0.83 MMP2 (0.33) SMN1; SMN2BLMCYP2C19CYP3A4TSHR
SCHEMBL8083418 0.81 ACP3 (0.42) PLK1CYP1A2CES2CES1CYP2C19
SCHEMBL8587107 0.81 SRC (0.42) MAPTSMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL8589711 0.78 CA2 (0.40) SMN1; SMN2BLMCYP2C19ALDH1A1CA1
SCHEMBL11109918 0.78 SRC (0.54) PLK1CYP1A1CYP1A2CYP1B1CES2
SCHEMBL3799753 0.77 MEN1 (0.50) CYP1A2SMN1; SMN2CYP2C19MEN1KMT2A
SCHEMBL8586119 0.77 ALDH1A1 (0.55) ALDH1A1CYP3A4TSHRHPGDHSD17B10
SCHEMBL8589186 0.77 SLC6A4 (0.39) SMN1; SMN2BLMCYP2C19ALDH1A1LMNA
SCHEMBL5940643 0.76 CES2 (0.35) PLK1CYP1A1CYP1A2CYP1B1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1057488-A1 INTERLEUKIN-6 PRODUCTION INHIBITORS TORAY INDUSTRIES, INC. (JP) 2000-12-06 EP claimed
EP-1057488-A1 INTERLEUKIN-6 PRODUCTION INHIBITORS TORAY INDUSTRIES, INC. (JP) 2000-12-06 EP disclosed
EP-0594857-B1 METHANEDIPHOSPHONIC ACID DERIVATIVE, PRODUCTION THEREOF AND MEDICINAL USE THEREOF TORAY INDUSTRIES (JP) 1998-04-29 EP disclosed
US-5683992-A TREATMENT OF RHEUMATISM, BONE DISORDERS, ANTIINFLAMMATORY, SUPPRESSION OF INTERLEUKIN-1, ANTIOXIDANT, TREATMENT OF AUTOIMMUNE DISEASES TORAY INDUSTRIES, INC. (JP) 1997-11-04 US disclosed
US-5527940-A SUPPRESSES INTERLEUKIN-1 AND BONE DESTRUCTION DURING OSTEOPOROSIS; ANTIINFLAMMATORY AGENTS TORAY INDUSTRIES, INC. (JP) 1996-06-18 US disclosed
EP-0594857-A1 METHANEDIPHOSPHONIC ACID DERIVATIVE, PRODUCTION THEREOF AND MEDICINAL USE THEREOF TORAY INDUSTRIES, INC. (JP) 1994-05-04 EP disclosed