Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | IDH2 | P48735 | 2/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587550 | 0.89 | GRIA4 (0.46) | GRIA4IDH2GRIA2KCNH2CNR1 | |
| SCHEMBL8585627 | 0.83 | NPY5R (0.37) | IDH2NPY5RCYP11B1CYP11B2FYN | |
| SCHEMBL8585587 | 0.82 | IDH2 (0.37) | GRIA4IDH2GRIA2NPY5RFYN | |
| SCHEMBL8583844 | 0.82 | KIF11 (0.46) | — | |
| SCHEMBL8585276 | 0.81 | ALDH1A1 (0.40) | GRIA4 | |
| SCHEMBL7570581 | 0.81 | CA12 (0.43) | GRIA4DRD3 | |
| SCHEMBL8586293 | 0.80 | CA12 (0.51) | GRIA4CNR1CYP1A2 | |
| SCHEMBL8585567 | 0.80 | L3MBTL1 (0.43) | — | |
| SCHEMBL8587469 | 0.80 | KIF11 (0.51) | — | |
| SCHEMBL8585612 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998033496-A1 | SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1998-08-06 | — | — | WO | disclosed |