Tromethamine

SCHEMBL8587709

CN(C)C(C)(C)CO.CN(C)C(C)(CO)CO.CN(C)C(CO)(CO)CO.NC(CO)(CO)CO

nearest known ligand 0.37

Known targets — ChEMBL curated mechanism

DHFR GART PTGFR PTGIR PTGS1 PTGS2 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 env murA thyA

The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	MEN1	O00255	1/20	0.37

▸	LMNA	P02545	1/20	0.37

▸	KMT2A	Q03164	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Tromethamine SCHEMBL8034308	0.92	MEN1 (0.43)	MEN1LMNAKMT2A
SCHEMBL8978	0.72	—	—
SCHEMBL423372	0.72	—	—
Ammonia Solution, Strong SCHEMBL11278632	0.70	—	—
SCHEMBL159962	0.69	ALDH1A1 (0.38)	—
Ethylenediamine SCHEMBL18009684	0.68	ALDH1A1 (0.30)	—
Hydrochloric Acid SCHEMBL6120200	0.67	—	—
Tromethamine SCHEMBL1759319	0.67	MEN1 (0.71)	MEN1LMNAKMT2A
Hydrochloric Acid SCHEMBL31692725	0.67	ALDH1A1 (0.36)	—
Tromethamine SCHEMBL8497866	0.65	MEN1 (0.67)	MEN1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-1998038972-A1	HAIR FIXING COMPOSITION	COLGATE-PALMOLIVE COMPANY (US)	1998-09-11	—	—	WO	disclosed