Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL8587709 | 0.92 | MEN1 (0.37) | MEN1LMNAKMT2A | |
| SCHEMBL423372 | 0.78 | — | — | |
| SCHEMBL159962 | 0.75 | ALDH1A1 (0.38) | — | |
| Hydrochloric Acid SCHEMBL31692725 | 0.72 | ALDH1A1 (0.36) | — | |
| Tromethamine SCHEMBL1759319 | 0.72 | MEN1 (0.71) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL29175316 | 0.70 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8497866 | 0.70 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7510306 | 0.69 | MEN1 (0.77) | MEN1LMNAKMT2A | |
| SCHEMBL6384223 | 0.69 | — | — | |
| Tromethamine SCHEMBL5655709 | 0.68 | MEN1 (0.62) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983040-A1 | HAIR FIXING COMPOSITION | Colgate-Palmolive Company (a Delaware corporation) (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998052517-A1 | HAIR FIXING COMPOSITION | COLGATE-PALMOLIVE COMPANY (US) | 1998-11-26 | — | — | WO | disclosed |