Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.45 |
| ▸ | GHSR | Q92847 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10470119 | 0.99 | MTNR1A (0.52) | MTNR1AMTNR1BGHSRGPR35ALDH1A1 | |
| SCHEMBL5541597 | 0.88 | MTNR1A (0.49) | MTNR1AMTNR1BALDH1A1MAPTHSD17B10 | |
| SCHEMBL8587828 | 0.81 | TAAR1 (0.53) | MTNR1AMTNR1BALDH1A1MAPTHSD17B10 | |
| SCHEMBL1253645 | 0.80 | GPR35 (0.51) | MTNR1AGPR35MAPTHTR2AMEN1 | |
| SCHEMBL1253768 | 0.80 | GPR35 (0.51) | MTNR1AGPR35MAPTHTR2AMEN1 | |
| SCHEMBL5547495 | 0.79 | ALOX5 (0.55) | GPR35ALDH1A1MAPTHSD17B10MEN1 | |
| SCHEMBL1548128 | 0.79 | GPR35 (0.44) | MTNR1AGPR35MAPTMEN1KMT2A | |
| SCHEMBL10663900 | 0.78 | MTNR1A (0.55) | MTNR1AMTNR1BALDH1A1MAPTHSD17B10 | |
| SCHEMBL27610613 | 0.78 | CYP2A6 (0.44) | MTNR1AGPR35MAPTMEN1KMT2A | |
| SCHEMBL5439262 | 0.77 | MTNR1A (0.44) | MTNR1AMTNR1BALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021492-A1 | e.g. sulfamic acid, 1,2,3,4-tetrahydro-dibenzothiophene-7-yl-1,1-dioxide ester; estrogen-dependent diseases | LABORATOIRE THERAMEX (MC) | 2007-01-25 | — | — | US | disclosed |
| EP-1644350-A1 | SULFAMATE BENZOTHIOPHENE DERIVATIVES AS STEROID SULFATASE INHIBITORS | LABORATOIRE THERAMEX (MC) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004101545-A1 | SULFAMATE BENZOTHIOPHENE DERIVATIVES AS STEROID SULFATASE INHIBITORS | LABORATOIRE THERAMEX (MC) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021492-A1 | e.g. sulfamic acid, 1,2,3,4-tetrahydro-dibenzothiophene-7-yl-1,1-dioxide ester; estrogen-dependent diseases | SULT1E1, SULT1A1, SULT2A1 | MTNR1A 26/4885MTNR1B 67/4885GHSR 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.