Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10470119 | 0.89 | MTNR1A (0.52) | MTNR1AMTNR1BMAPTALDH1A1HSD17B10 | |
| SCHEMBL5544113 | 0.88 | MTNR1A (0.51) | MTNR1AMTNR1BMAPTALDH1A1HSD17B10 | |
| SCHEMBL8587828 | 0.86 | TAAR1 (0.53) | MTNR1AMTNR1BMAPTALDH1A1HSD17B10 | |
| SCHEMBL10663900 | 0.83 | MTNR1A (0.55) | MTNR1AMTNR1BMAPTALDH1A1HSD17B10 | |
| SCHEMBL5439262 | 0.82 | MTNR1A (0.44) | MTNR1AMTNR1BMAPTALDH1A1HSD17B10 | |
| SCHEMBL6839987 | 0.82 | CYP2A6 (0.53) | MTNR1AMTNR1BMAPTALDH1A1HSD17B10 | |
| SCHEMBL5211436 | 0.82 | PPARG (0.46) | MTNR1AMTNR1BKMT2A | |
| SCHEMBL14099695 | 0.78 | LMNA (0.54) | MTNR1AMAPTALDH1A1HSD17B10SREBF2 | |
| SCHEMBL2878482 | 0.77 | PPARD (0.57) | MTNR1AMTNR1BHSD17B10KDM4E | |
| SCHEMBL5640485 | 0.77 | ALDH1A1 (0.54) | MTNR1AMTNR1BMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021492-A1 | e.g. sulfamic acid, 1,2,3,4-tetrahydro-dibenzothiophene-7-yl-1,1-dioxide ester; estrogen-dependent diseases | LABORATOIRE THERAMEX (MC) | 2007-01-25 | — | — | US | disclosed |
| EP-1644350-A1 | SULFAMATE BENZOTHIOPHENE DERIVATIVES AS STEROID SULFATASE INHIBITORS | LABORATOIRE THERAMEX (MC) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004101545-A1 | SULFAMATE BENZOTHIOPHENE DERIVATIVES AS STEROID SULFATASE INHIBITORS | LABORATOIRE THERAMEX (MC) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021492-A1 | e.g. sulfamic acid, 1,2,3,4-tetrahydro-dibenzothiophene-7-yl-1,1-dioxide ester; estrogen-dependent diseases | SULT1E1, SULT1A1, SULT2A1 | MTNR1A 26/4885MTNR1B 67/4885MAPT 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.