Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 3/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27835947 | 0.82 | PDE10A (0.44) | CCR1PDE10APARP1HTR3ANCF1 | |
| SCHEMBL26053800 | 0.81 | PARP1 (0.58) | CCR1PDE10APARP1HTR3ANCF1 | |
| SCHEMBL1507709 | 0.79 | PDE10A (0.42) | CCR1PDE10APARP1HTR3ANCF1 | |
| SCHEMBL1507910 | 0.79 | PDE10A (0.42) | CCR1PDE10APARP1HTR3ANCF1 | |
| SCHEMBL30461061 | 0.79 | PARP1 (0.49) | CCR1PDE10APARP1HTR3ANCF1 | |
| SCHEMBL5301328 | 0.79 | CCR1 (1.00) | CCR1PDE10APARP1CYP3A4TSHR | |
| SCHEMBL9220073 | 0.78 | CCR1 (0.65) | CCR1PDE10ANCF1PLAUHSD17B10 | |
| SCHEMBL28722027 | 0.77 | CCR1 (0.63) | CCR1PDE10APARP1NCF1PLAU | |
| SCHEMBL7806536 | 0.77 | CCR1 (0.63) | CCR1PDE10APARP1ALDH1A1KDM4E | |
| SCHEMBL30471553 | 0.77 | PDE10A (0.43) | CCR1PDE10APARP1HTR3AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140335019-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND ANALYSIS OF NEUROLOGICAL DISORDERS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-11-13 | — | — | US | disclosed |
| US-8709743-B2 | Inhibitors of bacterial nitric oxide synthase, and related screening methods | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-04-29 | — | — | US | disclosed |
| US-20110201042-A1 | Inhibitors of Bacterial Nitric Oxide Synthase, and Related Screening Methods | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-08-18 | — | — | US | disclosed |
| US-7494821-B2 | Fluorescein based sensors for tracking nitric oxide in live cells | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-02-24 | — | — | US | disclosed |
| US-20090017552-A1 | FLUORESCEIN BASED SENSORS FOR TRACKING NITRIC OXIDE IN LIVE CELLS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-01-15 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140335019-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND ANALYSIS OF NEUROLOGICAL DISORDERS | PSEN1, PSEN2, APP | CCR1 4747/4885PDE10A 1490/4885PARP1 3777/4885 |
| US-20110201042-A1 | Inhibitors of Bacterial Nitric Oxide Synthase, and Related Screening Methods | NOS1, NOS2, NOS3 | CCR1 4605/4885PDE10A 150/4885PARP1 4359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.