Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550 | 0.71 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| SCHEMBL31513481 | 0.68 | MAOA (0.39) | MAOAMAOBLMNAGAAOXTR | |
| SCHEMBL8925 | 0.68 | MAOA (0.39) | MAOAMAOBLMNAGAAOXTR | |
| SCHEMBL3928581 | 0.68 | MAOA (0.39) | MAOAMAOBLMNAGAAOXTR | |
| SCHEMBL7679301 | 0.67 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| Hydrochloric Acid SCHEMBL8707066 | 0.67 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| Hydrochloric Acid SCHEMBL8699855 | 0.67 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| Water SCHEMBL15284972 | 0.67 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| Methylamine SCHEMBL6415772 | 0.64 | MAOA (0.35) | MAOAMAOBKDM4ENPC1ALDH1A1 | |
| SCHEMBL3074959 | 0.64 | MAOA (0.50) | MAOAMAOBKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643317-A1 | BENZOXAZEPINES AS INHIBITORS OF P13K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012071519-A1 | BENZOXAZEPINES AS INHIBITORS OF P13K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-31 | — | — | WO | disclosed |