Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 2/20 | 0.46 |
| ▸ | GIPR | P48546 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8589911 | 0.87 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2POLBTDP1MEN1 | |
| SCHEMBL8590389 | 0.85 | SMN1; SMN2 (0.53) | MAPTSMN1; SMN2POLBTDP1MEN1 | |
| SCHEMBL8890493 | 0.82 | MAPT (0.74) | MAPTSMN1; SMN2POLBTDP1MEN1 | |
| SCHEMBL8591725 | 0.80 | MALT1 (0.55) | MAPTSMN1; SMN2MEN1KMT2AALPL | |
| SCHEMBL8592532 | 0.79 | PIN1 (0.64) | MAPTSMN1; SMN2POLBTDP1MEN1 | |
| SCHEMBL8592530 | 0.79 | PIN1 (0.64) | MAPTSMN1; SMN2POLBTDP1MEN1 | |
| SCHEMBL8430653 | 0.77 | RAB9A (0.59) | MAPTSMN1; SMN2POLBTDP1KMT2A | |
| SCHEMBL20488594 | 0.77 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2POLBTDP1MEN1 | |
| SCHEMBL4911657 | 0.77 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2POLBTDP1MEN1 | |
| SCHEMBL13425922 | 0.77 | MAPT (0.69) | MAPTSMN1; SMN2POLBTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744493-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5744491-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5635526-A | POSSESSES ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM OR THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1997-06-03 | — | — | US | disclosed |
| US-5616592-A | USEFUL FOR DISORDERS OF CARDIOVASCULAR, GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | SANOFI (FR) | 1997-04-01 | — | — | US | disclosed |
| US-5607958-A | NEUROTENSIN RECEPTOR BINDERS | SANOFI (FR) | 1997-03-04 | — | — | US | disclosed |
| US-5420141-A | Capable of binding to neurotensin receptor | SANOFI (FR) | 1995-05-30 | — | — | US | disclosed |