Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.37 |
| ▸ | BCL2 | P10415 | 3/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCKAR | P32238 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8593790 | 0.89 | MDM2 (0.37) | PTPN2PTPN1CDC25BCA1CA2 | |
| SCHEMBL8592529 | 0.74 | GCGR (0.40) | PTPN2PTPN1CDC25BPPARGPPARA | |
| SCHEMBL8591003 | 0.72 | CACNA1G (0.55) | MDM2MCL1BCL2CACNA1GCACNA1H | |
| SCHEMBL8591001 | 0.72 | CACNA1G (0.55) | MDM2MCL1BCL2CACNA1GCACNA1H | |
| SCHEMBL8591058 | 0.69 | RPA1 (0.73) | MDM2MCL1BCL2PPP1CARPA1 | |
| SCHEMBL8301692 | 0.67 | CACNA1G (0.49) | MDM2MCL1BCL2CACNA1GCACNA1H | |
| SCHEMBL8593794 | 0.67 | CACNA1G (0.49) | MDM2MCL1BCL2CACNA1GCACNA1H | |
| SCHEMBL8590028 | 0.67 | PPP1CA (0.59) | CA1CA2CA9MDM2MCL1 | |
| SCHEMBL7423057 | 0.67 | CYP1A2 (0.47) | MDM2 | |
| SCHEMBL7423062 | 0.67 | CYP1A2 (0.47) | MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744493-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5744491-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |