Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 5/20 | 0.73 |
| ▸ | PPP1CA | P62136 | 4/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.63 |
| ▸ | BCL2 | P10415 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MARS1 | P56192 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8590028 | 0.89 | PPP1CA (0.59) | RPA1PPP1CAL3MBTL1MDM2MCL1 | |
| SCHEMBL695352 | 0.85 | RPA1 (1.00) | RPA1PPP1CAL3MBTL1MDM2MCL1 | |
| SCHEMBL6457030 | 0.83 | MARS1 (0.62) | RPA1PPP1CAL3MBTL1MDM2MCL1 | |
| SCHEMBL4500796 | 0.81 | L3MBTL1 (1.00) | RPA1PPP1CAL3MBTL1MDM2MCL1 | |
| SCHEMBL27714729 | 0.81 | KMT2A (0.89) | RPA1PPP1CAL3MBTL1MDM2MCL1 | |
| SCHEMBL1987609 | 0.79 | RPA1 (0.82) | RPA1PPP1CAL3MBTL1MDM2MCL1 | |
| SCHEMBL24157617 | 0.78 | CYP2C9 (0.49) | RPA1MCL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27882807 | 0.78 | RAB9A (0.71) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL8591001 | 0.77 | CACNA1G (0.55) | RPA1PPP1CAMDM2MCL1BCL2 | |
| SCHEMBL8591003 | 0.77 | CACNA1G (0.55) | RPA1PPP1CAMDM2MCL1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744493-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5744491-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5635526-A | POSSESSES ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM OR THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1997-06-03 | — | — | US | disclosed |
| US-5616592-A | USEFUL FOR DISORDERS OF CARDIOVASCULAR, GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | SANOFI (FR) | 1997-04-01 | — | — | US | disclosed |
| US-5607958-A | NEUROTENSIN RECEPTOR BINDERS | SANOFI (FR) | 1997-03-04 | — | — | US | disclosed |
| US-5420141-A | Capable of binding to neurotensin receptor | SANOFI (FR) | 1995-05-30 | — | — | US | disclosed |