Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 2/20 | 0.55 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.55 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.47 |
| ▸ | MME | P08473 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | RPA1 | P27694 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | BCL2 | P10415 | 3/20 | 0.44 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591001 | 1.00 | CACNA1G (0.55) | CACNA1GCACNA1HPIN1MDM2MME | |
| SCHEMBL8301692 | 0.88 | CACNA1G (0.49) | CACNA1GCACNA1HPIN1MDM2RPA1 | |
| SCHEMBL8593794 | 0.88 | CACNA1G (0.49) | CACNA1GCACNA1HPIN1MDM2RPA1 | |
| SCHEMBL8296252 | 0.81 | CACNA1G (0.46) | CACNA1GCACNA1HPIN1MDM2RPA1 | |
| SCHEMBL8296254 | 0.81 | CACNA1G (0.46) | CACNA1GCACNA1HPIN1MDM2RPA1 | |
| SCHEMBL8591058 | 0.77 | RPA1 (0.73) | MDM2RPA1MEN1KMT2AMCL1 | |
| SCHEMBL8297233 | 0.76 | MDM2 (0.46) | CACNA1GCACNA1HMDM2MALT1MEN1 | |
| SCHEMBL8590028 | 0.75 | PPP1CA (0.59) | CACNA1GCACNA1HMDM2RPA1MALT1 | |
| SCHEMBL8592530 | 0.74 | PIN1 (0.64) | PIN1MMEACECPA1ACE2 | |
| SCHEMBL8592532 | 0.74 | PIN1 (0.64) | PIN1MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744491-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5744493-A | POSSESS ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM AND THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1998-04-28 | — | — | US | disclosed |
| US-5635526-A | POSSESSES ACTIVITY WITH RESPECT TO THE CENTRAL NERVOUS SYSTEM, THE CARDIOVASCULAR SYSTEM OR THE GASTROINTESTINAL SYSTEM | SANOFI (FR) | 1997-06-03 | — | — | US | disclosed |
| US-5616592-A | USEFUL FOR DISORDERS OF CARDIOVASCULAR, GASTROINTESTINAL AND PSYCHOLOGICAL DISORDERS | SANOFI (FR) | 1997-04-01 | — | — | US | disclosed |
| US-5607958-A | NEUROTENSIN RECEPTOR BINDERS | SANOFI (FR) | 1997-03-04 | — | — | US | disclosed |
| US-5420141-A | Capable of binding to neurotensin receptor | SANOFI (FR) | 1995-05-30 | — | — | US | disclosed |