Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 6/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375877 | 0.86 | EPHX1 (0.41) | ALDH1A1EPHX1ATMNAAAHPGD | |
| SCHEMBL18248174 | 0.79 | POLB (0.36) | ALDH1A1EPHX1ATMNAAAHPGD | |
| SCHEMBL7389962 | 0.79 | ALDH1A1 (0.44) | ALDH1A1EPHX1ATMNAAAHPGD | |
| SCHEMBL8694244 | 0.75 | ALDH1A1 (0.50) | ALDH1A1EPHX1ATMNAAAHPGD | |
| SCHEMBL10606733 | 0.73 | CTSK (0.41) | ALDH1A1EPHX1 | |
| SCHEMBL8710843 | 0.73 | TSHR (0.46) | ALDH1A1RAB9AL3MBTL1TSHR | |
| SCHEMBL5491470 | 0.73 | ATM (0.54) | ALDH1A1EPHX1ATMNAAAHPGD | |
| SCHEMBL10709704 | 0.72 | ESR1 (0.47) | SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL16298724 | 0.72 | EPHX1 (0.46) | ALDH1A1EPHX1ATMHPGDRAB9A | |
| SCHEMBL13519757 | 0.72 | EPHX1 (0.46) | ALDH1A1EPHX1ATMHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792150-A4 | 2-(2,3,5,6-TETRAFLUORO-4-PYRIDYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-03-11 | — | — | EP | disclosed |
| EP-0792150-A1 | 2-(2,3,5,6-TETRAFLUORO-4-PYRIDYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996016654-A1 | 2-(2,3,5,6-TETRAFLUORO-4-PYRIDYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |