Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 7/20 | 0.42 |
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622342 | 0.85 | SLC6A2 (0.44) | MEN1KMT2ASMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL8595287 | 0.77 | HTR7 (0.54) | HTTMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8556763 | 0.77 | HTT (0.54) | HTTMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL14294227 | 0.72 | NPC1 (0.56) | HTTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL8553855 | 0.70 | HTR2A (0.48) | HTTMEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL6338588 | 0.69 | SIGMAR1 (0.62) | HTTMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8557609 | 0.69 | SIGMAR1 (0.51) | MEN1KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL29212110 | 0.67 | NPC1 (0.61) | HTTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL29964126 | 0.67 | NPC1 (0.61) | HTTMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL14320162 | 0.66 | SLC6A2 (0.58) | HTTMAPTSMN1; SMN2RAB9ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | disclosed |