Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 11/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6338588 | 0.79 | SIGMAR1 (0.62) | HTR7DRD3HTR2CHTR2AMAPT | |
| SCHEMBL8556763 | 0.79 | HTT (0.54) | HTR7DRD3HTR2CHTR2AMAPT | |
| SCHEMBL8595290 | 0.77 | HTT (0.48) | HTR7DRD3HTR2CHTR2AMAPT | |
| SCHEMBL14294227 | 0.75 | NPC1 (0.56) | DRD3HTR2CHTR2AHTTMEN1 | |
| Sb-258719 SCHEMBL2471089 | 0.70 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3HTR2C | |
| SCHEMBL6337236 | 0.70 | HTR7 (0.68) | HTR7DRD2HTR2AALDH1A1HTR6 | |
| Sb-258719 SCHEMBL3688509 | 0.70 | HTR7 (0.98) | HTR7DRD2HTR1DDRD3HTR2C | |
| SCHEMBL14093297 | 0.69 | HTR7 (0.52) | HTR7HTR2CHTR2AALDH1A1 | |
| SCHEMBL14093532 | 0.69 | HTR2C (0.48) | HTR7DRD3HTR2CHTR2AMAPT | |
| SCHEMBL6340577 | 0.69 | HTR7 (0.70) | HTR7DRD2HTR2AALDH1A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | disclosed |