Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ASPH | Q12797 | 1/20 | 0.30 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566673 | 0.86 | KEAP1 (0.36) | MAPTKEAP1NFE2L2 | |
| SCHEMBL7813771 | 0.83 | KEAP1 (0.37) | MAPTKEAP1NFE2L2KDM4EASPH | |
| SCHEMBL9566655 | 0.79 | KEAP1 (0.34) | MAPTKEAP1NFE2L2KDM4EASPH | |
| SCHEMBL9566702 | 0.78 | MAPT (0.35) | MAPTKEAP1NFE2L2KDM4EASPH | |
| SCHEMBL9566689 | 0.77 | KEAP1 (0.33) | MAPTKEAP1NFE2L2 | |
| SCHEMBL9566700 | 0.77 | KEAP1 (0.33) | MAPTKEAP1NFE2L2 | |
| SCHEMBL8946844 | 0.76 | MAPT (0.41) | MAPTKEAP1NFE2L2KDM4EASPH | |
| SCHEMBL9566709 | 0.76 | LMNA (0.35) | MAPTKEAP1NFE2L2 | |
| SCHEMBL9566656 | 0.75 | KEAP1 (0.34) | MAPTKEAP1NFE2L2 | |
| SCHEMBL9566669 | 0.74 | MAPT (0.40) | MAPTKEAP1NFE2L2KDM4EASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667334-B1 | Process for the preparation of 4-alkoxy-3,5,6-trifluorophthalic acids and 3-alkoxy-2,4,5-trifluorobenzoic acids | CLARIANT GMBH (DE) | 1998-01-07 | — | — | EP | disclosed |
| US-5488152-A | Process for the preparation of 4-alkoxy-3,5,6-trifluoro-phthalic acids and 3-alkoxy-2,4,5-trifluorobenzoic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-01-30 | — | — | US | disclosed |
| EP-0667334-A2 | Process for the preparation of 4-alkoxy-3,5,6-trifluorophthalic acids and 3-alkoxy-2,4,5-trifluorobenzoic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-16 | — | — | EP | disclosed |