Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566655 | 0.89 | KEAP1 (0.34) | KEAP1NFE2L2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL9566656 | 0.87 | KEAP1 (0.34) | KEAP1NFE2L2MAPTEPAS1 | |
| SCHEMBL9566700 | 0.84 | KEAP1 (0.33) | KEAP1NFE2L2MAPT | |
| SCHEMBL7813771 | 0.81 | KEAP1 (0.37) | KEAP1NFE2L2AKR1C2AKR1C1MAPT | |
| SCHEMBL9566673 | 0.78 | KEAP1 (0.36) | KEAP1NFE2L2AKR1C2AKR1C1MAPT | |
| SCHEMBL9566689 | 0.78 | KEAP1 (0.33) | KEAP1NFE2L2MAPT | |
| SCHEMBL9566702 | 0.76 | MAPT (0.35) | KEAP1NFE2L2MAPT | |
| SCHEMBL8595294 | 0.76 | MAPT (0.35) | KEAP1NFE2L2MAPT | |
| SCHEMBL7804048 | 0.74 | KEAP1 (0.37) | KEAP1NFE2L2AKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL9566698 | 0.73 | KEAP1 (0.32) | KEAP1NFE2L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545866-A1 | Process for the preparation of trifluorobenzol derivatives | CIBA-GEIGY AG (CH) | 1993-06-09 | — | — | EP | disclosed |