Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.53 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 6/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7575609 | 0.80 | IMPDH2 (0.53) | IMPDH2IMPDH1MAOAMAOBALDH1A1 | |
| SCHEMBL16109256 | 0.80 | PDE4B (0.53) | ALDH1A1KDM4EUSP2PDE4APDE4B | |
| SCHEMBL28684149 | 0.79 | AR (0.50) | IMPDH2IMPDH1MAOAMAOBAR | |
| SCHEMBL6988623 | 0.78 | PDE4A (0.42) | MAOAMAOBPDE4APDE4BPDE4C | |
| SCHEMBL27608025 | 0.78 | IMPDH2 (0.47) | IMPDH2IMPDH1ALDH1A1KDM4EUSP2 | |
| SCHEMBL7274689 | 0.76 | SMN1; SMN2 (0.42) | MAOAMAOBALDH1A1KDM4EPDE4A | |
| SCHEMBL3432260 | 0.76 | IMPDH2 (0.49) | IMPDH2IMPDH1MAOAMAOBALDH1A1 | |
| SCHEMBL4696500 | 0.76 | ALDH1A1 (0.55) | IMPDH2IMPDH1MAOAMAOBALDH1A1 | |
| SCHEMBL29123961 | 0.76 | MAOB (0.57) | IMPDH2IMPDH1MAOAMAOBALDH1A1 | |
| SCHEMBL3643547 | 0.75 | NPC1 (0.54) | ALDH1A1KDM4EUSP2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877734-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-11-18 | — | — | EP | disclosed |
| WO-1997023462-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-07-03 | — | — | WO | disclosed |