SCHEMBL8599124

SCHEMBL8599124

C=CC(C)Oc1cc(N)c(F)cc1Cl

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.36
PPOX P50336 1/20 0.33
GAA P10253 1/20 0.33
CSNK2A1 P68400 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4678114 0.82 PPOX (0.45) NPC1PPOXGAACSNK2A1
SCHEMBL8879333 0.79 NPC1 (0.43) NPC1PPOXGAACSNK2A1
SCHEMBL10811265 0.76 NPC1 (0.38) NPC1PPOXGAA
SCHEMBL8599131 0.76 SLC2A1 (0.39) NPC1PPOXGAACSNK2A1
SCHEMBL9734857 0.75 EGFR (0.36) NPC1PPOXGAACSNK2A1
SCHEMBL9769676 0.75 NPC1 (0.36) NPC1PPOXGAACSNK2A1
SCHEMBL7689433 0.75 NPC1 (0.36) NPC1PPOXGAACSNK2A1
SCHEMBL8601346 0.75
SCHEMBL8602961 0.74 ALDH1A1 (0.47) PPOXGAA
SCHEMBL29278731 0.74 ALDH1A1 (0.47) PPOXGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0626370-B1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL CO (JP) 1998-02-11 EP disclosed
EP-0626370-A1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1994-11-30 EP disclosed