SCHEMBL8599205

SCHEMBL8599205

O=S(=O)(NF)C(F)(F)c1ccc(Oc2ncccn2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.44
LMNA P02545 5/20 0.44
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 3/20 0.44
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
APAF1 O14727 1/20 0.44
HTT P42858 2/20 0.43
TSHR P16473 1/20 0.43
RAB9A P51151 6/20 0.42
MAPT P10636 5/20 0.42
NPC1 O15118 3/20 0.42
POLB P06746 1/20 0.42
HPGD P15428 1/20 0.42
PTPN1 P18031 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C19 P33261 1/20 0.36
GAA P10253 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8599206 0.75 PTPN1 (0.71) SMN1; SMN2LMNAALDH1A1KDM4EMEN1
SCHEMBL296761 0.71 CA2 (0.57) ALDH1A1MEN1KMT2AHTTTSHR
SCHEMBL16473186 0.69 KMT2A (0.57) SMN1; SMN2LMNAALDH1A1KDM4EMEN1
SCHEMBL6943230 0.66 MEN1 (0.63) SMN1; SMN2LMNAALDH1A1KDM4EMEN1
SCHEMBL30565855 0.64 AHR (0.50) SMN1; SMN2KDM4EMEN1KMT2AHTT
SCHEMBL28840343 0.64 MEN1 (0.65) SMN1; SMN2LMNAALDH1A1KDM4EMEN1
SCHEMBL667594 0.63 MEN1 (0.64) SMN1; SMN2LMNAALDH1A1KDM4EMEN1
SCHEMBL2345370 0.62 MEN1 (1.00) SMN1; SMN2LMNAALDH1A1KDM4EMEN1
SCHEMBL1748538 0.62 MEN1 (0.63) SMN1; SMN2LMNAALDH1A1KDM4EMEN1
SCHEMBL806523 0.62 MEN1 (0.63) SMN1; SMN2LMNAALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10025213-A None JP disclosed
JP-H1025213-A HERBICIDAL COMPOSITION COMPRISING SULFONAMIDE DERIVATIVE AND PRETILACHLOR SANKYO CO LTD 1998-01-27 JP disclosed