Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596888 | 0.81 | CYP2A13 (0.48) | SIGMAR1POLBSMN1; SMN2DRD4DRD2 | |
| SCHEMBL5752961 | 0.75 | DRD2 (0.50) | SIGMAR1POLBSMN1; SMN2DRD4DRD2 | |
| SCHEMBL30438100 | 0.75 | SYK (0.49) | POLBLMNA | |
| SCHEMBL2161659 | 0.72 | DRD2 (0.73) | SIGMAR1POLBSMN1; SMN2DRD4DRD2 | |
| SCHEMBL7081357 | 0.70 | DRD2 (0.49) | SIGMAR1POLBSMN1; SMN2DRD4DRD2 | |
| SCHEMBL5546676 | 0.70 | SIGMAR1 (0.60) | SIGMAR1POLBSMN1; SMN2DRD4DRD2 | |
| SCHEMBL5546683 | 0.70 | DRD4 (0.66) | SIGMAR1POLBSMN1; SMN2DRD4DRD2 | |
| SCHEMBL28145809 | 0.69 | SIGMAR1 (0.56) | SIGMAR1POLBSMN1; SMN2HTR1AHTR2C | |
| SCHEMBL5750042 | 0.69 | MAPT (0.58) | SIGMAR1SMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL2924810 | 0.68 | SIGMAR1 (0.51) | SIGMAR1POLBSMN1; SMN2HTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |