Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599595 | 0.92 | TP53 (0.53) | TP53ALDH1A1APEX1CYP2C9CYP2C19 | |
| SCHEMBL8596165 | 0.88 | TP53 (0.45) | TP53CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL8601785 | 0.87 | TP53 (0.48) | TP53ALDH1A1APEX1CYP2C9CYP2C19 | |
| SCHEMBL8601684 | 0.87 | RXFP1 (0.44) | TP53ALDH1A1APEX1MAPTKDM4E | |
| SCHEMBL8602071 | 0.84 | MAPT (0.46) | TP53ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8601062 | 0.80 | TP53 (0.47) | TP53ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL8597312 | 0.79 | TP53 (0.43) | TP53CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL8597937 | 0.78 | TP53 (0.43) | TP53SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL8601161 | 0.76 | TP53 (0.46) | TP53ALDH1A1APEX1CYP2C9CYP2C19 | |
| SCHEMBL8595161 | 0.76 | PTGES (0.42) | TP53ALDH1A1APEX1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |