Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599169 | 0.85 | PIK3CD (0.39) | PIK3CDPIK3R1PIK3CAPIK3CBMEN1 | |
| SCHEMBL8597312 | 0.84 | TP53 (0.43) | MEN1KMT2ACRHBPHTTCRHR2 | |
| SCHEMBL8597130 | 0.82 | MEN1 (0.38) | MEN1KMT2ACRHBPHTTCRHR2 | |
| SCHEMBL8571701 | 0.82 | TAS1R3 (0.42) | MEN1KMT2ACRHBPHTTCRHR2 | |
| Trifluoroacetic Acid SCHEMBL8598750 | 0.81 | CDK4 (0.42) | MEN1KMT2ACRHBPHTTCRHR2 | |
| SCHEMBL8569083 | 0.76 | MMP2 (0.43) | MEN1KMT2ACRHBPHTTCRHR2 | |
| SCHEMBL8601626 | 0.75 | MAPT (0.47) | MEN1KMT2ACRHBPHTTCRHR2 | |
| SCHEMBL8598838 | 0.75 | TP53 (0.43) | MEN1KMT2ACRHBPHTTCRHR2 | |
| SCHEMBL8601890 | 0.75 | TNF (0.46) | MEN1KMT2ACRHBPHTTCRHR2 | |
| SCHEMBL8597093 | 0.75 | MMP2 (0.42) | MEN1KMT2ACRHBPHTTCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944592-A1 | VITAMIN D3 DERIVATIVES | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1999-09-29 | — | — | EP | disclosed |
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1998024762-A1 | VITAMIN D3 DERIVATIVES | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-06-11 | — | — | WO | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |