Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 8/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.33 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 3/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.31 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8603224 | 0.82 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8599642 | 0.81 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8601087 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL8601399 | 0.81 | MEN1 (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8600001 | 0.80 | CNR1 (0.40) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL8601071 | 0.79 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL8602159 | 0.79 | BRD4 (0.41) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL8601274 | 0.78 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DICMT | |
| SCHEMBL8600463 | 0.78 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8604472 | 0.78 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |