Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | ICMT | O60725 | 3/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599642 | 0.86 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601071 | 0.85 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DHDAC1 | |
| SCHEMBL8601399 | 0.85 | MEN1 (0.39) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601267 | 0.83 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8600463 | 0.82 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8604472 | 0.82 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DICMT | |
| SCHEMBL8601171 | 0.78 | NR1D1 (0.40) | PDE4APDE4BPDE4CPDE4DICMT | |
| SCHEMBL8603224 | 0.76 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8649978 | 0.76 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DICMT | |
| SCHEMBL8601087 | 0.76 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |