Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601399 | 0.91 | MEN1 (0.39) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8604472 | 0.88 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8600463 | 0.88 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601274 | 0.86 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601267 | 0.84 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601171 | 0.81 | NR1D1 (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8603224 | 0.80 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8601087 | 0.79 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL8600001 | 0.77 | CNR1 (0.40) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL8602159 | 0.76 | BRD4 (0.41) | PDE4APDE4BPDE4CPDE4DBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |