Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CFB | P00751 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599642 | 0.88 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DMAOA | |
| SCHEMBL8601399 | 0.87 | MEN1 (0.39) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601071 | 0.85 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8604472 | 0.84 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601274 | 0.82 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601267 | 0.81 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601171 | 0.78 | NR1D1 (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8603224 | 0.76 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8601087 | 0.76 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL8604538 | 0.76 | HTR6 (0.42) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |