Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 8/20 | 0.43 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29254314 | 0.86 | CLCN2 (0.54) | CLCN2KDM4E | |
| SCHEMBL7589368 | 0.83 | DHODH (0.42) | DHODHLTB4R2DCLRE1BBCL2L1BAD | |
| SCHEMBL10644876 | 0.83 | MRGPRX4 (0.49) | CLCN2DHODHKDM4E | |
| SCHEMBL18983054 | 0.82 | CLCN2 (0.56) | CLCN2KDM4EHTT | |
| SCHEMBL4238088 | 0.75 | KAT6A (0.54) | CLCN2KDM4E | |
| Fluorobenzene SCHEMBL27572385 | 0.74 | CLCN2 (0.49) | CLCN2DCLRE1BCYP1A2CYP2C19KMT2A | |
| SCHEMBL9518777 | 0.73 | DCLRE1B (0.55) | DCLRE1BBCL2L1BADKDM4ETTR | |
| SCHEMBL28373110 | 0.73 | FOLH1 (0.55) | CLCN2DCLRE1BKDM4EHTT | |
| SCHEMBL21856149 | 0.73 | CLCN2 (0.41) | CLCN2 | |
| SCHEMBL3843394 | 0.73 | HNF4A (0.55) | CLCN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998056752-A1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES | NPS PHARMACEUTICALS, INC. (US) | 1998-12-17 | — | — | WO | disclosed |