Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 4/20 | 0.44 |
| ▸ | FABP3 | P05413 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29254314 | 0.85 | CLCN2 (0.54) | HNF4AMAPTKDM4EPIM1GFER | |
| SCHEMBL6782256 | 0.84 | HNF4A (0.49) | HNF4AMAPTKDM4EPIM1GFER | |
| SCHEMBL1931921 | 0.84 | DCLRE1B (0.56) | HNF4AMAPTKDM4EPIM1GFER | |
| SCHEMBL70098 | 0.82 | HNF4A (0.63) | HNF4AMAPTKDM4EPIM1GFER | |
| SCHEMBL374696 | 0.80 | FOLH1 (0.61) | MAPTKDM4EALDH1A1ALOX15FOLH1 | |
| SCHEMBL8653763 | 0.80 | FOLH1 (0.45) | HNF4AMAPTKDM4EPIM1GFER | |
| SCHEMBL30209232 | 0.79 | WDR5 (0.44) | HNF4AMAPTKDM4EPIM1GFER | |
| SCHEMBL225203 | 0.79 | HNF4A (0.71) | HNF4AMAPTKDM4EPIM1GFER | |
| SCHEMBL28391136 | 0.78 | HNF4A (0.59) | HNF4AMAPTKDM4EPIM1GFER | |
| SCHEMBL8768476 | 0.78 | FOLH1 (0.59) | MAPTKDM4EALDH1A1ALOX15FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906684-B2 | Antioxidants | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-03-15 | — | — | US | disclosed |
| US-7622612-B2 | Tricyclic derivatives and their use | CHEMTECH RESEARCH INCORPORATION (KR) | 2009-11-24 | — | — | US | disclosed |
| US-7622612-B2 | Tricyclic derivatives and their use | CHEMTECH RESEARCH INCORPORATION (KR) | 2009-11-24 | — | — | US | disclosed |
| US-20090246158-A1 | ANTIOXIDANTS | MERCK PATENT GESELLSCHAFT (DE) | 2009-10-01 | — | — | US | disclosed |
| US-20070021427-A1 | Novel tricyclic derivatives and their use | CHEMTECH RESEARCH INCORPORATION (KR) | 2007-01-25 | — | — | US | disclosed |
| US-20070021427-A1 | Novel tricyclic derivatives and their use | CHEMTECH RESEARCH INCORPORATION (KR) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090246158-A1 | ANTIOXIDANTS | LPO, GPX1, GPX4 | HNF4A 3956/4885MAPT 1568/4885KDM4E 4182/4885 |
| US-20070021427-A1 | Novel tricyclic derivatives and their use | NFATC1, IL2, CCL2 | HNF4A 2449/4885MAPT 392/4885KDM4E 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.