Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600301 | 0.94 | PIK3C2B (0.46) | MAPTSMN1; SMN2TP53PIK3C2BKDM4E | |
| SCHEMBL8598135 | 0.93 | IRAK4 (0.44) | MAPTSMN1; SMN2IRAK4TSHRGAA | |
| SCHEMBL8668207 | 0.89 | IRAK4 (0.45) | MAPTSMN1; SMN2TP53PIK3C2BKDM4E | |
| SCHEMBL8602071 | 0.84 | MAPT (0.46) | MAPTSMN1; SMN2TP53KDM4EIRAK4 | |
| SCHEMBL8602363 | 0.84 | PIK3C2B (0.52) | MAPTSMN1; SMN2TP53PIK3C2BKDM4E | |
| SCHEMBL8595628 | 0.79 | MAPT (0.52) | MAPTSMN1; SMN2TP53PIK3C2BKDM4E | |
| SCHEMBL8599500 | 0.78 | ALDH1A1 (0.51) | MAPTSMN1; SMN2IRAK4ALDH1A1GAA | |
| SCHEMBL13990316 | 0.77 | IRAK4 (0.49) | MAPTSMN1; SMN2PIK3C2BIRAK4ALDH1A1 | |
| SCHEMBL8602825 | 0.77 | TSHR (0.52) | MAPTIRAK4TSHRALDH1A1 | |
| SCHEMBL8601859 | 0.76 | DCTPP1 (0.54) | MAPTSMN1; SMN2TP53PIK3C2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |