Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13979951 | 0.77 | KMT2A (0.53) | PHGDHALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL321368 | 0.76 | ALDH1A1 (0.67) | ALDH1A1LMNATSHRCYP3A4CYP2C19 | |
| SCHEMBL9871267 | 0.76 | MGLL (0.49) | PHGDHALDH1A1TSHRCYP3A4CYP2C19 | |
| SCHEMBL12483318 | 0.75 | LMNA (0.42) | ALDH1A1LMNACYP3A4HPGDKMT2A | |
| SCHEMBL12483316 | 0.75 | LMNA (0.42) | ALDH1A1LMNACYP3A4HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL10943241 | 0.75 | ALDH1A1 (0.65) | ALDH1A1LMNATSHRCYP3A4CYP2C19 | |
| Morpholino(Phenyl)Methanethione SCHEMBL9180076 | 0.75 | MGLL (0.79) | PHGDHALDH1A1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL19357132 | 0.74 | PHGDH (1.00) | PHGDHALDH1A1LMNATSHRHPGD | |
| SCHEMBL8662309 | 0.74 | TSHR (0.56) | PHGDHALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL946143 | 0.73 | HPGD (0.86) | PHGDHALDH1A1LMNATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548680-B1 | Beta-oxo-beta-benzenepropanethioamide derivatives | MITSUBISHI CHEM CORP (JP) | 1998-02-25 | — | — | EP | disclosed |
| US-5439927-A | For potassium channel opening, hypotensive agents, broncho- or vasodilators, gastrointestinal disorders | MITSUBISHI KASEI CORPORATION (JP) | 1995-08-08 | — | — | US | disclosed |
| US-5332833-A | Potassium channel modulator, hypotensive, hypersensitive colon syndrome, asthma, enteritis | MITSUBISHI KASEI CORPORATION (JP) | 1994-07-26 | — | — | US | disclosed |
| EP-0548680-A1 | Beta-oxo-beta-benzenepropanethioamide derivatives | Mitsubishi Chemical Corporation (JP) | 1993-06-30 | — | — | EP | disclosed |