Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ATM | Q13315 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599412 | 0.98 | KDM4E (0.54) | KDM4EATMHTTRAD52PGR | |
| SCHEMBL27212869 | 0.82 | KDM4E (0.43) | KDM4EATMHTTRAD52PGR | |
| SCHEMBL11542025 | 0.79 | MEN1 (0.38) | KDM4EATMHTTCA9PARP1 | |
| SCHEMBL11545783 | 0.79 | HDAC4 (0.37) | ACHECA1CA2CA7CA9 | |
| SCHEMBL29341181 | 0.79 | S100A4 (0.38) | KDM4EMETAP1CA1CA2CA4 | |
| SCHEMBL11547924 | 0.79 | PDE7A (0.42) | PGRMETAP1PARP1PARP10LRRK2 | |
| SCHEMBL11544646 | 0.79 | PBRM1 (0.44) | KDM4ECA1CA2CA7CA9 | |
| SCHEMBL13001156 | 0.79 | KDM4E (0.40) | KDM4EATMHTTHRH3 | |
| SCHEMBL11819535 | 0.79 | PARP10 (0.41) | KDM4EATMHTTRAD52PGR | |
| SCHEMBL8596234 | 0.79 | GRIN1 (0.46) | KDM4EMETAP1ACHECA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | disclosed |
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |