Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 5/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600310 | 0.73 | LCK (0.40) | RAB9APDK1PDK2PDK3PDK4 | |
| SCHEMBL8602077 | 0.72 | ALDH1A1 (0.39) | KMT2ASMN1; SMN2 | |
| SCHEMBL8598941 | 0.72 | TYK2 (0.43) | KMT2APTGESTYK2SMN1; SMN2JAK2 | |
| SCHEMBL8596745 | 0.72 | PTGES (0.36) | KMT2APTGESTYK2PDE4BPDE4A | |
| SCHEMBL8603464 | 0.71 | HTT (0.44) | KMT2APTGESLMNAMAPTMAPK14 | |
| SCHEMBL8598381 | 0.69 | ALDH1A1 (0.41) | KMT2APTGESLMNAPDK1PDK2 | |
| SCHEMBL8597937 | 0.69 | TP53 (0.43) | KMT2APTGESTYK2SMN1; SMN2 | |
| SCHEMBL8598365 | 0.68 | TYK2 (0.44) | KMT2APTGESTYK2PDE4BPDE4A | |
| SCHEMBL8599534 | 0.68 | LMNA (0.41) | KMT2APTGESTYK2LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8599168 | 0.68 | SLC11A2 (0.38) | PTGESTYK2PDE4BLMNAPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |