SCHEMBL8602

SCHEMBL8602

O=c1c(-c2cccc(F)c2)coc2ccccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 0.61
MAOB P27338 6/20 0.52
SMN1; SMN2 Q16637 7/20 0.51
NPC1 O15118 6/20 0.51
ALDH1A1 P00352 6/20 0.51
RAB9A P51151 6/20 0.51
KDM4E B2RXH2 5/20 0.51
POLB P06746 2/20 0.51
GABRP O00591 1/20 0.51
GABRD O14764 1/20 0.51
GABRA1 P14867 1/20 0.51
GABRB1 P18505 1/20 0.51
GABRG2 P18507 1/20 0.51
GABRB3 P28472 1/20 0.51
GABRA5 P31644 1/20 0.51
GABRA3 P34903 1/20 0.51
GABRA2 P47869 1/20 0.51
GABRB2 P47870 1/20 0.51
GABRA4 P48169 1/20 0.51
GABRE P78334 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29651545 1.00 MIF (0.61) MIFMAOBSMN1; SMN2NPC1ALDH1A1
SCHEMBL30586191 0.88 PTPN1 (0.54) MIFSMN1; SMN2NPC1ALDH1A1RAB9A
SCHEMBL29651755 0.88 PTPN1 (0.54) MIFSMN1; SMN2NPC1ALDH1A1RAB9A
SCHEMBL4366639 0.83 KDM4E (0.73) MIFMAOBSMN1; SMN2NPC1ALDH1A1
SCHEMBL2853275 0.83 NPC1 (0.64) MIFMAOBSMN1; SMN2NPC1ALDH1A1
SCHEMBL21253091 0.83 NPC1 (0.64) MIFMAOBSMN1; SMN2NPC1ALDH1A1
Isoflavone SCHEMBL31264756 0.82 ALDH1A1 (0.66) MIFMAOBSMN1; SMN2NPC1ALDH1A1
Isoflavone SCHEMBL8028 0.82 ALDH1A1 (0.66) MIFMAOBSMN1; SMN2NPC1ALDH1A1
Isoflavone SCHEMBL6290885 0.82 ALDH1A1 (0.66) MIFMAOBSMN1; SMN2NPC1ALDH1A1
Isoflavone SCHEMBL6542422 0.82 ALDH1A1 (0.66) MIFMAOBSMN1; SMN2NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240139198-A1 METHOD AND COMBINATION FOR TREATING TUMORS CURON BIOPHARMACEUTICAL (SHANGHAI) CO., LIMITED (CN) 2024-05-02 US claimed
EP-4292596-A1 METHOD AND COMBINATION FOR TREATING TUMORS Curon Biopharmaceutical (Shanghai) Co., Limited (CN) 2023-12-20 EP claimed
WO-2022171121-A1 METHOD AND COMBINATION FOR TREATING TUMORS 同润生物医药(上海)有限公司 2022-08-18 WO claimed
EP-2914343-A1 COMBINATION OF ANTI-CD20 ANTIBODY AND PI3 KINASE SELECTIVE INHIBITOR TG Therapeutics Inc. (US) 2015-09-09 EP claimed
WO-2014071125-A1 COMBINATION OF ANTI-CD20 ANTIBODY AND PI3 KINASE SELECTIVE INHIBITOR TG THERAPEUTICS, INC. (US) 2014-05-08 WO claimed
EP-2496567-A2 NOVEL BENZOPYRAN KINASE MODULATORS Rhizen Pharmaceuticals S.A. (CH) 2012-09-12 EP claimed
WO-2011055215-A2 NOVEL KINASE MODULATORS INCOZEN THERAPEUTICS PVT. LTD. (IN) 2011-05-12 WO claimed
US-20240139198-A1 METHOD AND COMBINATION FOR TREATING TUMORS CURON BIOPHARMACEUTICAL (SHANGHAI) CO., LIMITED (CN) 2024-05-02 US disclosed
EP-4292596-A1 METHOD AND COMBINATION FOR TREATING TUMORS Curon Biopharmaceutical (Shanghai) Co., Limited (CN) 2023-12-20 EP disclosed
WO-2023123742-A1 SEMI-FUMARATE CRYSTAL OF PI3Kδ/γ DUAL INHIBITOR COMPOUND, AND PREPARATION METHOD THEREFOR 同润生物医药(上海)有限公司 2023-07-06 WO disclosed
WO-2022171121-A1 METHOD AND COMBINATION FOR TREATING TUMORS 同润生物医药(上海)有限公司 2022-08-18 WO disclosed
EP-3004106-A1 DUAL SELECTIVE PI3 DELTA AND GAMMA KINASE INHIBITORS Rhizen Pharmaceuticals S.A. (CH) 2016-04-13 EP disclosed
EP-2916868-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR Rhizen Pharmaceuticals S.A. (CH) 2015-09-16 EP disclosed
EP-2496567-A2 NOVEL BENZOPYRAN KINASE MODULATORS Rhizen Pharmaceuticals S.A. (CH) 2012-09-12 EP disclosed
WO-2011055215-A2 NOVEL KINASE MODULATORS INCOZEN THERAPEUTICS PVT. LTD. (IN) 2011-05-12 WO disclosed
WO-2010042933-A9 INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS NORTHWESTERN UNIVERSITY (US) 2010-07-08 WO disclosed
US-20100137425-A1 INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS NORTHWESTERN UNIVERSITY (US) 2010-06-03 US disclosed
US-20100137425-A1 INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS NORTHWESTERN UNIVERSITY (US) 2010-06-03 US disclosed
WO-2010042933-A2 INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS NORTHWESTERN UNIVERSITY (US) 2010-04-15 WO disclosed
WO-2009049214-A2 INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS NORTHWESTERN UNIVERSITY (US) 2009-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240139198-A1 METHOD AND COMBINATION FOR TREATING TUMORS PDCD1, PDCD1LG2, CD274 MIF 368/4885MAOB 4250/4885SMN1; SMN2 4576/4885
US-20100137425-A1 INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS MAPK4, MAP4K4, MAP3K4 MIF 574/4885MAOB 2694/4885SMN1; SMN2 4692/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.