Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596537 | 0.89 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKCNK3 | |
| SCHEMBL8600336 | 0.85 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4DTHRB | |
| SCHEMBL8598294 | 0.83 | DCTPP1 (0.40) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8598135 | 0.79 | IRAK4 (0.44) | KMT2ADHODHMAPT | |
| SCHEMBL8598511 | 0.72 | PTGES (0.41) | KMT2ATP53POLBPTGES | |
| SCHEMBL8598600 | 0.71 | THRB (0.42) | PDE4APDE4BPDE4CPDE4DTHRB | |
| SCHEMBL8595606 | 0.71 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8598543 | 0.71 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL8601221 | 0.70 | HPGD (0.46) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8600059 | 0.70 | PTGES (0.40) | PDE4APDE4BPDE4CPDE4DTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |